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Choose a place to check the patient’s readiness for injection

  • Readiness for injection includes confirming no signs of infection and no elevated temperature
  • Patients can be assessed for readiness by telemedicine
  • In-person screening can be done in any private area at your practice to promote distancing


Keeping an unopened box of CIMZIA at room temperature is an option* that allows it to be reconstituted immediately, helping cut prep and wait time for your patients. A qualified medical professional can be trained to reconstitute CIMZIA.

  • Reconstitution in ≤30 min
  • Patients can wait anywhere during reconstitution to reduce contact
    • For example: the waiting room, a patient room, an infusion suite, a car, or other open areas outside the office

*Unopened box can be refrigerated. Do not leave reconstituted CIMZIA at room temperature for more than 2 hours prior to administration. Once reconstituted, CIMZIA can be stored in the vials for up to 24 hours between 2° and 8°C (36°to 46°F) prior to injection. Do not freeze. For full information on storing options, visit



Choose where to administer CIMZIA.

  • Can be administered in any private area at your practice, such as an exam room or infusion suite, to promote distancing
  • No additional supplies needed to reconstitute or administer

The same medical professional can reconstitute and administer CIMZIA to limit exposure.

  • Reconstitute in ≤30 minutes and administer in minutes


For patients who have been confirmed to stay on treatment, scheduling two or three appointments for loading/maintenance treatment before the patient leaves can help them stay on track.

  • Patients can leave within minutes after their injection
  • CIMZIA does not require any post-treatment monitoring
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Explore how the process can work in your office

Answer this questionnaire to explore options. You'll receive a downloadable resource when you complete the questionnaire.

Which of these best describes your practice?
Which of these statements describes how you schedule CIMZIA In-Office Injection appointments?
Check which most often applies.
CIMZIA has three loading doses in the first month (400 mg at weeks 0, 2, and 4).1*
Do you schedule these initial loading dose appointments at the same time?
*Please see Section 2 of full Prescribing Information for additional dosing and administration information. 

CIMZIA kits may be kept at room temperature for up to 6 months, but not exceeding the original expiration date. Unopened kits stored at room temperature may be reconstituted immediately upon patient arrival to your practice so patients do not have to wait longer.

How do you store CIMZIA In-Office Injection kits and bring them to room temperature?

Do not leave reconstituted CIMZIA at room temperature for more than 2 hours prior to administration. Once reconstituted, CIMZIA can be stored in the vials for up to 24 hours between 2° and 8°C (36° to 46°F) prior to injection. Do not freeze.1 

If storing at room temperature, write the new expiration date in the space provided on the kit.

Before reconstituting CIMZIA, it’s important to ensure the patient’s readiness for injection (e.g. no sign of infection, no elevated temperature). 

Where do you assess the patient’s readiness for injection?

Check which most often applies.

As social norms change, patients may want to limit time around other patients. 

Once deemed ready for injection, where in your practice do patients wait while the CIMZIA In-Office Injection is being reconstituted?

You may have a need to minimize the exposure of your patients to other people.

Does the same person who assessed the patient’s readiness for injection also reconstitute the CIMZIA In-Office Injection?
Who reconstitutes CIMZIA in your practice?
‡Scope of practice laws for medical assistants providing injections may vary by state. 

Once reconstituted, CIMZIA is ready to be injected.

Where in your practice do you inject your patients?
Does the same person who reconstitutes CIMZIA also administer it?
Who administers CIMZIA in your practice?
‡Scope of practice laws for medical assistants providing injections may vary by state.

It is important to help patients stay on track with their treatment when clinically appropriate.

For maintenance doses, how are follow-up appointments typically scheduled in your office?

Click the button below to see your answers and different ways to support your patients in office.

Want to know more about the process?

Request a representative for more information about how the in-office injection process can work in your office.


Treatment for busy patients

CIMZIA offers a different patient experience for your patients who need in-office treatment.

See the difference

Affordability and copay for patients

Help your patients understand their prescription savings options.

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Download helpful resources

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Serious and sometimes fatal side effects have been reported with CIMZIA, including tuberculosis (TB), bacterial sepsis, invasive fungal infections (such as histoplasmosis), and infections due to other opportunistic pathogens (such as Legionella or Listeria). Patients should be closely monitored for the signs and symptoms of infection during and after treatment with CIMZIA. Lymphoma and other malignancies, some fatal, have been reported in children and adolescent patients treated with TNF blockers, of which CIMZIA is a member. CIMZIA is not indicated for use in pediatric patients.


CIMZIA is indicated for:

  • Reducing signs and symptoms of Crohn’s disease (CD) and maintaining clinical response in adult patients with moderately to severely active disease who have had an inadequate response to conventional therapy
  • Treatment of adults with moderately to severely active rheumatoid arthritis (RA)
  • Treatment of adult patients with active psoriatic arthritis (PsA)
  • Treatment of adult patients with active ankylosing spondylitis (AS)
  • Treatment of adults with moderate-to-severe plaque psoriasis (PSO) who are candidates for systemic therapy or phototherapy
  • Treatment of adults with active non-radiographic axial spondyloarthritis (nr-axSpA) with objective signs of inflammation



CIMZIA is contraindicated in patients with a history of hypersensitivity reaction to certolizumab pegol or to any of the excipients. Reactions have included angioedema, anaphylaxis, serum sickness, and urticaria.


Patients treated with CIMZIA are at increased risk for developing serious infections that may lead to hospitalization or death. Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids.

Discontinue CIMZIA if a patient develops a serious infection or sepsis.

Reported infections include:

  • Active tuberculosis (TB), including reactivation of latent TB. Patients with TB have frequently presented with disseminated or extrapulmonary disease. Test patients for latent TB before CIMZIA use and during therapy. Initiate treatment for latent TB prior to CIMZIA use.
  • Invasive fungal infections, including histoplasmosis, coccidioidomycosis, candidiasis, aspergillosis, blastomycosis, and pneumocystosis. Patients with histoplasmosis or other invasive fungal infections may present with disseminated, rather than localized, disease. Antigen and antibody testing for histoplasmosis may be negative in some patients with active infection. Consider empiric anti-fungal therapy in patients at risk for invasive fungal infections who develop severe systemic illness.
  • Bacterial, viral, and other infections due to opportunistic pathogens, including Legionella and Listeria.

Carefully consider the risks and benefits of treatment with CIMZIA prior to initiating therapy in the following patients: with chronic or recurrent infection; who have been exposed to TB; with a history of opportunistic infection; who resided in or traveled in regions where mycoses are endemic; with underlying conditions that may predispose them to infection. Monitor patients closely for the development of signs and symptoms of infection during and after treatment with CIMZIA, including the possible development of TB in patients who tested negative for latent TB infection prior to initiating therapy.

  • Do not start CIMZIA during an active infection, including localized infections.
  • Patients older than 65 years, patients with co-morbid conditions, and/or patients taking concomitant immunosuppressants may be at greater risk of infection.
  • If an infection develops, monitor carefully and initiate appropriate therapy.


Lymphoma and other malignancies, some fatal, have been reported in children and adolescent patients treated with TNF blockers, of which CIMZIA is a member. CIMZIA is not indicated for use in pediatric patients.

  • Consider the risks and benefits of CIMZIA treatment prior to initiating or continuing therapy in a patient with known malignancy.
  • In clinical trials, more cases of malignancies were observed among CIMZIA-treated patients compared to control patients.
  • In CIMZIA clinical trials, there was an approximately 2-fold higher rate of lymphoma than expected in the general U.S. population. Patients with rheumatoid arthritis, particularly those with highly active disease, are at a higher risk of lymphoma than the general population.
  • Malignancies, some fatal, have been reported among children, adolescents, and young adults being treated with TNF blockers. Approximately half of the cases were lymphoma, while the rest were other types of malignancies, including rare types associated with immunosuppression and malignancies not usually seen in this patient population.
  • Postmarketing cases of hepatosplenic T-cell lymphoma (HSTCL), a rare type of T-cell lymphoma, have been reported in patients treated with TNF blockers, including CIMZIA. These cases have had a very aggressive disease course and have been fatal. The majority of reported TNF blocker cases have occurred in patients with Crohn’s disease or ulcerative colitis, and the majority were in adolescent and young adult males. Almost all of these patients had received treatment with azathioprine or 6-mercaptopurine concomitantly with a TNF blocker at or prior to diagnosis. Carefully assess the risks and benefits of treating with CIMZIA in these patient types.
  • Cases of acute and chronic leukemia were reported with TNF blocker use.


  • Worsening and new onset congestive heart failure (CHF) have been reported with TNF blockers. Exercise caution and monitor carefully.


  • Angioedema, anaphylaxis, dyspnea, hypotension, rash, serum sickness, and urticaria have been reported following CIMZIA administration. If a serious allergic reaction occurs, stop CIMZIA and institute appropriate therapy. The needle shield inside the removable cap of the CIMZIA prefilled syringe contains a derivative of natural rubber latex which may cause an allergic reaction in individuals sensitive to latex.


  • Use of TNF blockers, including CIMZIA, may increase the risk of reactivation of hepatitis B virus (HBV) in patients who are chronic carriers. Some cases have been fatal.
  • Test patients for HBV infection before initiating treatment with CIMZIA.
  • Exercise caution in patients who are carriers of HBV and monitor them before and during CIMZIA treatment.
  • Discontinue CIMZIA and begin antiviral therapy in patients who develop HBV reactivation. Exercise caution when resuming CIMZIA after HBV treatment.


  • TNF blockers, including CIMZIA, have been associated with rare cases of new onset or exacerbation of central nervous system and peripheral demyelinating diseases, including multiple sclerosis, seizure disorder, optic neuritis, peripheral neuropathy, and Guillain-Barré syndrome.


  • Rare reports of pancytopenia, including aplastic anemia, have been reported with TNF blockers. Medically significant cytopenia has been infrequently reported with CIMZIA.
  • Consider stopping CIMZIA if significant hematologic abnormalities occur.


  • Do not use CIMZIA in combination with other biological DMARDS.


  • Treatment with CIMZIA may result in the formation of autoantibodies and, rarely, in development of a lupus-like syndrome. Discontinue treatment if symptoms of a lupus-like syndrome develop.


  • Patients on CIMZIA should not receive live or live-attenuated vaccines.


  • The most common adverse reactions in CIMZIA clinical trials (≥8%) were upper respiratory infections (18%), rash (9%), and urinary tract infections (8%).

Please see full Prescribing Information.